Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

HIPK4

protein_coding 19 40,379,271 - 40,390,181 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000160396

Gene type
protein_coding

Chromosome
19

Coordinates
40,379,271 - 40,390,181

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

147746 CCDS12555 ENST00000291823.3 FLJ32818 NM_144685 NM_144685.5 Q8NE63

Summary

GENCODE gene_type=protein_coding; HGNC symbol=HIPK4; HGNC name=homeodomain interacting protein kinase 4; alias_count=7; RefSeq=NM_144685; UniProt=Q8NE63; MANE Select=ENST00000291823.3,NM_144685.5

Source: GENCODE + HGNC complete set

147746 • protein-coding

This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]

NCBI Gene

UniProt

Q8NE63 • reviewed

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential)

Homeodomain-interacting protein kinase 4 · Cytoplasm · EC 2.7.11.1

GO annotations

Biological process

GO:0006338 chromatin remodeling (IEA)

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IBA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IBA)

Molecular function

GO:0005524 ATP binding (IEA)
GO:0035173 histone kinase activity (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0004672 protein kinase activity (IEA)
GO:0004672 protein kinase activity (IEA)
GO:0106310 protein serine kinase activity (IEA)
GO:0004674 protein serine/threonine kinase activity (IEA)

+ 2 more

Representative

Representative transcript
ENST00000291823

Representative protein
ENSP00000291823.1

Representative type
CCDS

Candidate count
1

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000291823	HIPK4-201	protein_coding	not available	ENSP00000291823.1	19:40,379,271 - 40,390,181 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.