Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

GTPBP4

protein_coding 10 988,409 - 1,020,001 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000107937

Gene type
protein_coding

Chromosome
10

Coordinates
988,409 - 1,020,001

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

23560 CCDS31132 CRFG ENST00000360803.9 FLJ10686 FLJ10690 G protein-binding protein CRFG GTP-binding protein NGB NM_012341 NM_012341.3 NOG1 Q9BZE4

Summary

GENCODE gene_type=protein_coding; HGNC symbol=GTPBP4; HGNC name=GTP binding protein 4; alias_count=13; RefSeq=NM_012341; UniProt=Q9BZE4; MANE Select=ENST00000360803.9,NM_012341.3

Source: GENCODE + HGNC complete set

23560 • protein-coding

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9BZE4 • reviewed

Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539)

GTP-binding protein 4 · Nucleus, nucleolus

GO annotations

Biological process

GO:0008156 negative regulation of DNA replication (IMP)
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle (IDA)
GO:0030336 negative regulation of cell migration (IDA)
GO:0008285 negative regulation of cell population proliferation (IMP)
GO:0022408 negative regulation of cell-cell adhesion (IDA)
GO:0031397 negative regulation of protein ubiquitination (IDA)
GO:0001649 osteoblast differentiation (HDA)
GO:0050821 protein stabilization (IDA)
GO:0042273 ribosomal large subunit biogenesis (IDA)
GO:0042273 ribosomal large subunit biogenesis (IBA)

+ 1 more

Cellular component

GO:0005737 cytoplasm (IDA)
GO:0016020 membrane (HDA)
GO:0016020 membrane (HDA)
GO:0005730 nucleolus (IEA)
GO:0005730 nucleolus (IDA)
GO:0005730 nucleolus (IBA)
GO:0005634 nucleus (IDA)
GO:0005634 nucleus (HDA)
GO:0048471 perinuclear region of cytoplasm (IDA)

Molecular function

GO:0005525 GTP binding (IEA)
GO:0005525 GTP binding (IDA)
GO:0003924 GTPase activity (IDA)
GO:0003924 GTPase activity (IBA)
GO:0003723 RNA binding (HDA)
GO:0003723 RNA binding (HDA)
GO:0003723 RNA binding (IBA)
GO:1990275 preribosome binding (IDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 3 more

Representative

Representative transcript
ENST00000360803

Representative protein
ENSP00000354040.4

Representative type
CCDS

Candidate count
2

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00001089852	GTPBP4-223	nonsense_mediated_decay	not available	ENSP00000759658.1	10:988,409 - 1,017,773 +
ENST00000892145	GTPBP4-206	protein_coding	not available	ENSP00000562204.1	10:988,418 - 1,020,001 +
ENST00000892146	GTPBP4-207	protein_coding	not available	ENSP00000562205.1	10:988,418 - 1,020,001 +
ENST00000892147	GTPBP4-208	protein_coding	not available	ENSP00000562206.1	10:988,418 - 1,020,001 +
ENST00000892148	GTPBP4-209	protein_coding	not available	ENSP00000562207.1	10:988,418 - 1,020,001 +
ENST00000892149	GTPBP4-210	protein_coding	not available	ENSP00000562208.1	10:988,418 - 1,017,683 +
ENST00000925420	GTPBP4-212	protein_coding	not available	ENSP00000595479.1	10:988,418 - 1,020,001 +
ENST00000925421	GTPBP4-213	protein_coding	not available	ENSP00000595480.1	10:988,418 - 1,020,001 +
ENST00000925422	GTPBP4-214	protein_coding	not available	ENSP00000595481.1	10:988,418 - 1,020,001 +
ENST00000925423	GTPBP4-215	protein_coding	not available	ENSP00000595482.1	10:988,418 - 1,020,001 +
ENST00000925424	GTPBP4-216	protein_coding	not available	ENSP00000595483.1	10:988,418 - 1,020,001 +
ENST00000925425	GTPBP4-217	protein_coding	not available	ENSP00000595484.1	10:988,418 - 1,020,001 +
ENST00001108670	GTPBP4-225	protein_coding	not available	ENSP00000778475.1	10:988,418 - 1,009,683 +
ENST00001125833	GTPBP4-226	protein_coding	not available	ENSP00000795638.1	10:988,418 - 1,008,460 +
ENST00001129272	GTPBP4-227	protein_coding	not available	ENSP00000799077.1	10:988,418 - 996,429 +
ENST00001136197	GTPBP4-228	protein_coding	not available	ENSP00000808867.1	10:988,418 - 1,020,001 +
ENST00001089855	GTPBP4-224	nonsense_mediated_decay	not available	ENSP00000759661.1	10:988,432 - 1,017,703 +
ENST00000996264	GTPBP4-218	nonsense_mediated_decay	not available	ENSP00000666081.1	10:988,433 - 1,018,439 +
ENST00000360803	GTPBP4-202	protein_coding	not available	ENSP00000354040.4	10:988,434 - 1,019,932 +
ENST00001035930	GTPBP4-219	nonsense_mediated_decay	not available	ENSP00000705747.1	10:988,434 - 1,017,760 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.