Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

GPS1

protein_coding 17 82,050,691 - 82,058,063 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000169727

Gene type
protein_coding

Chromosome
17

Coordinates
82,050,691 - 82,058,063

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

2873 CCDS11800 CCDS32774 CCDS82225 CCDS82226 CCDS82227 CCDS82228 CCDS92418 COP9 signalosome subunit 1 COPS1 CSN1 ENST00000578552.6 NM_001321092.3 NM_212492 Q13098

Summary

GENCODE gene_type=protein_coding; HGNC symbol=GPS1; HGNC name=G protein pathway suppressor 1; alias_count=15; RefSeq=NM_212492; UniProt=Q13098; MANE Select=ENST00000578552.6,NM_001321092.3

Source: GENCODE + HGNC complete set

2873 • protein-coding

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

NCBI Gene

UniProt

Q13098 • reviewed

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G protein- and mitogen-activated protein kinase-mediated signal transduction

COP9 signalosome complex subunit 1 · Cytoplasm; Nucleus

Q13098 • reviewed

COP9 signalosome complex subunit 1 · Cytoplasm; Nucleus

Q13098 • reviewed

COP9 signalosome complex subunit 1 · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0007254 JNK cascade (TAS)
GO:0000338 protein deneddylation (IDA)
GO:0045116 protein neddylation (NAS)
GO:2000434 regulation of protein neddylation (NAS)

Cellular component

GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IPI)
GO:0008180 COP9 signalosome (IBA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (IDA)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)

+ 6 more

Molecular function

GO:0005095 GTPase inhibitor activity (TAS)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 5 more

Representative

Representative transcript
ENST00000306823

Representative protein
ENSP00000302873.6

Representative type
CCDS

Candidate count
12

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000583983	GPS1-222	protein_coding_CDS_not_defined	not available	not available	17:82,050,691 - 82,051,837 +
ENST00000582327	GPS1-216	protein_coding	not available	ENSP00000464575.1	17:82,050,948 - 82,054,651 +
ENST00000585084	GPS1-225	protein_coding	not available	ENSP00000462391.1	17:82,051,175 - 82,054,968 +
ENST00000580716	GPS1-212	protein_coding	not available	ENSP00000463690.1	17:82,051,477 - 82,054,741 +
ENST00000583961	GPS1-221	protein_coding	not available	ENSP00000463381.1	17:82,051,500 - 82,054,586 +
ENST00000306823	GPS1-201	protein_coding	not available	ENSP00000302873.6	17:82,051,873 - 82,058,063 +
ENST00000623691	GPS1-226	protein_coding	not available	ENSP00000485330.1	17:82,051,873 - 82,058,063 +
ENST00000624957	GPS1-228	protein_coding	not available	ENSP00000485641.1	17:82,051,873 - 82,058,063 +
ENST00000706669	GPS1-229	protein_coding	not available	ENSP00000516490.1	17:82,051,873 - 82,058,063 +
ENST00000706670	GPS1-230	protein_coding	not available	ENSP00000516491.1	17:82,051,873 - 82,058,063 +
ENST00000909667	GPS1-231	protein_coding	not available	ENSP00000579726.1	17:82,051,873 - 82,058,063 +
ENST00000909668	GPS1-232	protein_coding	not available	ENSP00000579727.1	17:82,051,873 - 82,058,063 +
ENST00000909669	GPS1-233	protein_coding	not available	ENSP00000579728.1	17:82,051,873 - 82,058,063 +
ENST00000909670	GPS1-234	protein_coding	not available	ENSP00000579729.1	17:82,051,873 - 82,057,470 +
ENST00000909671	GPS1-235	protein_coding	not available	ENSP00000579730.1	17:82,051,873 - 82,058,063 +
ENST00000909672	GPS1-236	protein_coding	not available	ENSP00000579731.1	17:82,051,873 - 82,058,063 +
ENST00000909673	GPS1-237	protein_coding	not available	ENSP00000579732.1	17:82,051,873 - 82,058,063 +
ENST00000909674	GPS1-238	protein_coding	not available	ENSP00000579733.1	17:82,051,873 - 82,058,063 +
ENST00000909675	GPS1-239	protein_coding	not available	ENSP00000579734.1	17:82,051,873 - 82,058,063 +
ENST00000909676	GPS1-240	protein_coding	not available	ENSP00000579735.1	17:82,051,873 - 82,058,063 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.