Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

GNL3L

GNL3L

protein_coding X 54,529,900 - 54,621,565 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000130119

Gene type
protein_coding

Chromosome
X

Coordinates
54,529,900 - 54,621,565

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

54552 CCDS14360 ENST00000360845.3 FLJ10613 G protein nucleolar 3B GNL3B NM_001184819.2 NM_019067 Q9NVN8 guanine nucleotide binding protein-like 3 (nucleolar)-like

Summary

GENCODE gene_type=protein_coding; HGNC symbol=GNL3L; HGNC name=G protein nucleolar 3 like; alias_count=10; RefSeq=NM_019067; UniProt=Q9NVN8; MANE Select=ENST00000360845.3,NM_001184819.2

Source: GENCODE + HGNC complete set

54552 • protein-coding

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

NCBI Gene

UniProt

Q9NVN8 • reviewed

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP

Guanine nucleotide-binding protein-like 3-like protein · Nucleus, nucleolus

Q9NVN8 • reviewed

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP

Guanine nucleotide-binding protein-like 3-like protein · Nucleus, nucleolus

Q9NVN8 • reviewed

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP

Guanine nucleotide-binding protein-like 3-like protein · Nucleus, nucleolus

Q9NVN8 • reviewed

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP

Guanine nucleotide-binding protein-like 3-like protein · Nucleus, nucleolus

Q9NVN8 • reviewed

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP

Guanine nucleotide-binding protein-like 3-like protein · Nucleus, nucleolus

GO annotations

Biological process

GO:0033234 negative regulation of protein sumoylation (IMP)
GO:0031397 negative regulation of protein ubiquitination (IMP)
GO:0032211 negative regulation of telomere maintenance via telomerase (IMP)
GO:1904816 positive regulation of protein localization to chromosome, telomeric region (IDA)
GO:1904816 positive regulation of protein localization to chromosome, telomeric region (IMP)
GO:0031334 positive regulation of protein-containing complex assembly (IMP)
GO:0031647 regulation of protein stability (IDA)
GO:0031647 regulation of protein stability (IMP)

Cellular component

GO:0016020 membrane (HDA)
GO:0005730 nucleolus (IEA)
GO:0005730 nucleolus (IDA)
GO:0005730 nucleolus (IEA)
GO:0005730 nucleolus (IDA)
GO:0005730 nucleolus (IBA)
GO:0005697 telomerase holoenzyme complex (IDA)

Molecular function

GO:0005525 GTP binding (IEA)
GO:0003723 RNA binding (HDA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 12 more

Representative

Representative transcript
ENST00000336470

Representative protein
ENSP00000338573.4

Representative type
CCDS

Candidate count
11

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=2

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000336470	GNL3L-201	protein_coding	not available	ENSP00000338573.4	X:54,529,900 - 54,567,289 +
ENST00000674225	GNL3L-205	protein_coding	not available	ENSP00000501441.1	X:54,529,900 - 54,567,289 +
ENST00000674420	GNL3L-210	protein_coding	not available	ENSP00000501418.1	X:54,529,900 - 54,567,289 +
ENST00000674498	GNL3L-211	protein_coding	not available	ENSP00000501411.1	X:54,529,900 - 54,621,565 +
ENST00000873404	GNL3L-213	protein_coding	not available	ENSP00000543463.1	X:54,529,900 - 54,621,565 +
ENST00000873405	GNL3L-214	protein_coding	not available	ENSP00000543464.1	X:54,529,900 - 54,621,565 +
ENST00000873407	GNL3L-216	protein_coding	not available	ENSP00000543466.1	X:54,529,900 - 54,567,289 +
ENST00000873408	GNL3L-217	protein_coding	not available	ENSP00000543467.1	X:54,529,900 - 54,567,289 +
ENST00000924105	GNL3L-219	protein_coding	not available	ENSP00000594164.1	X:54,529,900 - 54,567,289 +
ENST00000949607	GNL3L-220	protein_coding	not available	ENSP00000619666.1	X:54,529,900 - 54,567,289 +
ENST00000949608	GNL3L-221	protein_coding	not available	ENSP00000619667.1	X:54,529,900 - 54,567,289 +
ENST00000674229	GNL3L-206	nonsense_mediated_decay	not available	ENSP00000501385.1	X:54,530,183 - 54,560,853 +
ENST00001033178	GNL3L-222	nonsense_mediated_decay	not available	ENSP00000702995.1	X:54,530,188 - 54,561,070 +
ENST00000674300	GNL3L-208	retained_intron	not available	not available	X:54,530,203 - 54,550,026 +
ENST00000674178	GNL3L-204	nonsense_mediated_decay	not available	ENSP00000501380.1	X:54,530,209 - 54,560,940 +
ENST00000360845	GNL3L-202	protein_coding	not available	ENSP00000354091.2	X:54,530,219 - 54,567,289 +
ENST00000674311	GNL3L-209	protein_coding	not available	ENSP00000501452.1	X:54,530,219 - 54,567,289 +
ENST00000873406	GNL3L-215	protein_coding	not available	ENSP00000543465.1	X:54,530,219 - 54,621,565 +
ENST00001116501	GNL3L-228	protein_coding	not available	ENSP00000786306.1	X:54,530,219 - 54,550,119 +
ENST00001033179	GNL3L-223	nonsense_mediated_decay	not available	ENSP00000702996.1	X:54,530,234 - 54,561,093 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.