Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

FBXO22

FBXO22

protein_coding 15 75,903,853 - 75,942,511 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000167196
Gene type
protein_coding
Chromosome
15
Coordinates
75,903,853 - 75,942,511
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

26263 CCDS10287 CCDS45310 ENST00000308275.8 F-box only protein 22 FBX22 FIST domain containing 1 FISTC1 NM_147188 NM_147188.3 Q8NEZ5

Summary

GENCODE gene_type=protein_coding; HGNC symbol=FBXO22; HGNC name=F-box protein 22; alias_count=11; RefSeq=NM_147188; UniProt=Q8NEZ5; MANE Select=ENST00000308275.8,NM_147188.3

Source: GENCODE + HGNC complete set

26263 • protein-coding

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

NCBI Gene

UniProt

Q8NEZ5 • reviewed

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933)

F-box only protein 22 · Cytoplasm; Nucleus; Cytoplasm, myofibril, sarcomere, Z line

Q8NEZ5 • reviewed

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933)

F-box only protein 22 · Cytoplasm; Nucleus; Cytoplasm, myofibril, sarcomere, Z line

Q8NEZ5 • reviewed

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels (PubMed:21768309). In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage (PubMed:26868148). Under oxidative stress, promotes the ubiquitination and degradation of BACH1. Mechanistically, reactive oxygen species (ROS) covalently modify cysteine residues on the bZIP domain of BACH1, leading to its release from chromatin and making it accessible to FBXO22 (PubMed:39504958). Upon amino acid depletion, mediates 'Lys-27'-linked ubiquitination of MTOR and thereby inhibits substrate recruitment to mTORC1 (PubMed:37979583). Also inhibits SARS-CoV-2 replication by inducing NSP5 degradation (PubMed:39223933)

F-box only protein 22 · Cytoplasm; Nucleus; Cytoplasm, myofibril, sarcomere, Z line

GO annotations

Biological process
  • GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (NAS)
  • GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IBA)
  • GO:0036211 protein modification process (TAS)
  • GO:0000209 protein polyubiquitination (IBA)
  • GO:0048742 regulation of skeletal muscle fiber development (IBA)
  • GO:0006511 ubiquitin-dependent protein catabolic process (TAS)
Cellular component
  • GO:0019005 SCF ubiquitin ligase complex (NAS)
  • GO:0030018 Z disc (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 10 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0004842 ubiquitin-protein transferase activity (TAS)

Representative

Representative transcript
ENST00000308275
Representative protein
ENSP00000307833.3
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000453211 FBXO22-202 protein_coding not available ENSP00000396442.2 15:75,903,853 - 75,930,655 +
ENST00000929297 FBXO22-210 protein_coding not available ENSP00000599356.1 15:75,903,853 - 75,934,107 +
ENST00000929298 FBXO22-211 protein_coding not available ENSP00000599357.1 15:75,903,853 - 75,933,130 +
ENST00001066259 FBXO22-225 protein_coding not available ENSP00000736065.1 15:75,903,853 - 75,933,510 +
ENST00001094586 FBXO22-227 protein_coding not available ENSP00000764392.1 15:75,903,853 - 75,934,596 +
ENST00001119453 FBXO22-228 protein_coding not available ENSP00000789258.1 15:75,903,853 - 75,933,824 +
ENST00001128751 FBXO22-229 protein_coding not available ENSP00000798556.1 15:75,903,853 - 75,934,936 +
ENST00001136874 FBXO22-231 protein_coding not available ENSP00000805945.1 15:75,903,853 - 75,942,511 +
ENST00000992031 FBXO22-212 nonsense_mediated_decay not available ENSP00000661848.1 15:75,903,861 - 75,935,787 +
ENST00000992032 FBXO22-213 nonsense_mediated_decay not available ENSP00000661849.1 15:75,903,870 - 75,934,608 +
ENST00000569749 FBXO22-209 nonsense_mediated_decay not available ENSP00000456198.1 15:75,903,876 - 75,930,847 +
ENST00001066254 FBXO22-222 nonsense_mediated_decay not available ENSP00000736060.1 15:75,903,876 - 75,935,268 +
ENST00000308275 FBXO22-201 protein_coding not available ENSP00000307833.3 15:75,903,878 - 75,942,511 +
ENST00000569022 FBXO22-207 nonsense_mediated_decay not available ENSP00000457531.1 15:75,903,878 - 75,934,107 +
ENST00000992035 FBXO22-216 nonsense_mediated_decay not available ENSP00000661852.1 15:75,903,878 - 75,934,110 +
ENST00000992036 FBXO22-217 nonsense_mediated_decay not available ENSP00000661853.1 15:75,903,878 - 75,934,106 +
ENST00001066255 FBXO22-223 nonsense_mediated_decay not available ENSP00000736061.1 15:75,903,880 - 75,934,597 +
ENST00000992033 FBXO22-214 nonsense_mediated_decay not available ENSP00000661850.1 15:75,903,881 - 75,934,607 +
ENST00001066256 FBXO22-224 nonsense_mediated_decay not available ENSP00000736062.1 15:75,903,881 - 75,934,597 +
ENST00001023111 FBXO22-221 nonsense_mediated_decay not available ENSP00000692928.1 15:75,903,883 - 75,930,655 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.