Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

DDX24

protein_coding 14 94,048,287 - 94,081,216 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000089737

Gene type
protein_coding

Chromosome
14

Coordinates
94,048,287 - 94,081,216

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

57062 CCDS9918 DEAD (Asp-Glu-Ala-Asp) box helicase 24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24 ENST00000621632.5 NM_020414 NM_020414.4 Q9GZR7

Summary

GENCODE gene_type=protein_coding; HGNC symbol=DDX24; HGNC name=DEAD-box helicase 24; alias_count=9; RefSeq=NM_020414; UniProt=Q9GZR7; MANE Select=ENST00000621632.5,NM_020414.4

Source: GENCODE + HGNC complete set

57062 • protein-coding

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q9GZR7 • reviewed

ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity (PubMed:24204270, PubMed:24980433). Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation (PubMed:25867071). Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation (PubMed:36298642). Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA (By similarity) (Microbial infection) Plays a positive role in HIV-1 infection by promoting Rev-dependent nuclear export of viral RNAs and their packaging into virus particles (PubMed:24204270)

ATP-dependent RNA helicase DDX24 · Cytoplasm; Nucleus · EC 3.6.4.13

GO annotations

Biological process

GO:0016070 RNA metabolic process (NAS)

Cellular component

GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (EXP)
GO:0016020 membrane (HDA)
GO:0005730 nucleolus (IDA)
GO:0005730 nucleolus (IBA)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (EXP)

Molecular function

GO:0005524 ATP binding (IEA)
GO:0016887 ATP hydrolysis activity (IEA)
GO:0003723 RNA binding (HDA)
GO:0003723 RNA binding (HDA)
GO:0003724 RNA helicase activity (IEA)
GO:0003724 RNA helicase activity (IEA)
GO:0003724 RNA helicase activity (NAS)
GO:0003676 nucleic acid binding (IEA)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 1 more

Representative

Representative transcript
ENST00000621632

Representative protein
ENSP00000481495.1

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000544005	DDX24-201	protein_coding	not available	ENSP00000440623.1	14:94,048,287 - 94,081,202 -
ENST00000555054	DDX24-204	protein_coding	not available	ENSP00000452145.1	14:94,048,287 - 94,081,216 -
ENST00000621632	DDX24-208	protein_coding	not available	ENSP00000481495.1	14:94,048,287 - 94,081,202 -
ENST00000900312	DDX24-209	protein_coding	not available	ENSP00000570371.1	14:94,048,287 - 94,081,216 -
ENST00000900313	DDX24-210	protein_coding	not available	ENSP00000570372.1	14:94,048,287 - 94,081,216 -
ENST00000900314	DDX24-211	protein_coding	not available	ENSP00000570373.1	14:94,048,287 - 94,081,216 -
ENST00000900316	DDX24-213	protein_coding	not available	ENSP00000570375.1	14:94,048,287 - 94,081,216 -
ENST00000934361	DDX24-214	protein_coding	not available	ENSP00000604420.1	14:94,048,287 - 94,081,216 -
ENST00000946905	DDX24-215	protein_coding	not available	ENSP00000616964.1	14:94,048,287 - 94,081,216 -
ENST00000946906	DDX24-216	protein_coding	not available	ENSP00000616965.1	14:94,048,287 - 94,080,592 -
ENST00001135838	DDX24-222	protein_coding	not available	ENSP00000814704.1	14:94,048,287 - 94,081,216 -
ENST00001064447	DDX24-219	nonsense_mediated_decay	not available	ENSP00000734253.1	14:94,050,904 - 94,081,208 -
ENST00001024238	DDX24-217	nonsense_mediated_decay	not available	ENSP00000694055.1	14:94,050,914 - 94,081,210 -
ENST00001024239	DDX24-218	nonsense_mediated_decay	not available	ENSP00000694056.1	14:94,050,919 - 94,081,210 -
ENST00000555762	DDX24-206	retained_intron	not available	not available	14:94,050,920 - 94,081,198 -
ENST00000900315	DDX24-212	protein_coding	not available	ENSP00000570374.1	14:94,050,921 - 94,081,216 -
ENST00000553400	DDX24-202	protein_coding_CDS_not_defined	not available	not available	14:94,050,922 - 94,051,824 -
ENST00000553451	DDX24-203	protein_coding_CDS_not_defined	not available	not available	14:94,050,922 - 94,056,163 -
ENST00001064449	DDX24-220	nonsense_mediated_decay	not available	ENSP00000734255.1	14:94,050,922 - 94,081,210 -
ENST00000556635	DDX24-207	retained_intron	not available	not available	14:94,051,188 - 94,053,378 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.