Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

DCLRE1A

protein_coding 10 113,834,725 - 113,854,417 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000198924

Gene type
protein_coding

Chromosome
10

Coordinates
113,834,725 - 113,854,417

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

9937 CCDS7584 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) ENST00000361384.7 KIAA0086 NM_014881 NM_014881.5 PSO2 PSO2 homolog (S. cerevisiae) Q6PJP8 SNM1 hSNM1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=DCLRE1A; HGNC name=DNA cross-link repair 1A; alias_count=13; RefSeq=NM_014881; UniProt=Q6PJP8; MANE Select=ENST00000361384.7,NM_014881.5

Source: GENCODE + HGNC complete set

9937 • protein-coding

This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

NCBI Gene

UniProt

Q6PJP8 • reviewed

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986)

DNA cross-link repair 1A protein · Nucleus · EC 3.5.2.6

Q6PJP8 • reviewed

DNA cross-link repair 1A protein · Nucleus · EC 3.5.2.6

GO annotations

Biological process

GO:0006281 DNA repair (IEA)
GO:0006303 double-strand break repair via nonhomologous end joining (IBA)
GO:0036297 interstrand cross-link repair (IBA)

Cellular component

GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)
GO:0005634 nucleus (IEA)
GO:0005634 nucleus (IBA)

Molecular function

GO:0035312 5'-3' DNA exonuclease activity (IDA)
GO:0035312 5'-3' DNA exonuclease activity (IBA)
GO:0003677 DNA binding (IEA)
GO:0008800 beta-lactamase activity (IEA)
GO:0008800 beta-lactamase activity (IDA)
GO:0003684 damaged DNA binding (IBA)

Representative

Representative transcript
ENST00000361384

Representative protein
ENSP00000355185.2

Representative type
CCDS

Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000361384	DCLRE1A-201	protein_coding	not available	ENSP00000355185.2	10:113,834,725 - 113,854,082 -
ENST00000369305	DCLRE1A-202	protein_coding	not available	ENSP00000358311.1	10:113,834,725 - 113,854,417 -
ENST00000852021	DCLRE1A-204	protein_coding	not available	ENSP00000522080.1	10:113,834,725 - 113,854,328 -
ENST00001125449	DCLRE1A-205	nonsense_mediated_decay	not available	ENSP00000795254.1	10:113,834,725 - 113,854,222 -
ENST00000476112	DCLRE1A-203	protein_coding_CDS_not_defined	not available	not available	10:113,853,243 - 113,854,340 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.