Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS9

COPS9

protein_coding 2 240,126,563 - 240,136,807 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000172428
Gene type
protein_coding
Chromosome
2
Coordinates
240,126,563 - 240,136,807
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

150678 CCDS2532 CCDS63183 CSN acidic protein CSNAP ENST00000607357.2 MYEOV2 NM_001163424.2 NM_138336 Q8WXC6 myeloma overexpressed 2

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS9; HGNC name=COP9 signalosome subunit 9; alias_count=11; RefSeq=NM_138336; UniProt=Q8WXC6; MANE Select=ENST00000607357.2,NM_001163424.2

Source: GENCODE + HGNC complete set

150678 • protein-coding

Alliance of Genome Resources Involved in cellular response to UV; negative regulation of protein neddylation; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q8WXC6 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation Negatively regulates neddylation of proteins, including ribosoaml protein RPL11

COP9 signalosome complex subunit 9 · Nucleus; Cytoplasm; Nucleus, nucleoplasm

Q8WXC6 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation Negatively regulates neddylation of proteins, including ribosoaml protein RPL11

COP9 signalosome complex subunit 9 · Nucleus; Cytoplasm; Nucleus, nucleoplasm

GO annotations

Biological process
  • GO:0034644 cellular response to UV (IDA)
  • GO:1904750 negative regulation of protein localization to nucleolus (IMP)
  • GO:2000435 negative regulation of protein neddylation (IMP)
  • GO:0008284 positive regulation of cell population proliferation (IMP)
Cellular component
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0000785 chromatin (IDA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005654 nucleoplasm (IEA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005634 nucleus (IEA)
  • GO:0005634 nucleus (IDA)
Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000307266
Representative protein
ENSP00000304147.3
Representative type
CCDS
Candidate count
3

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000307266 COPS9-201 protein_coding not available ENSP00000304147.3 2:240,126,563 - 240,136,347 -
ENST00000924049 COPS9-206 protein_coding not available ENSP00000594108.1 2:240,130,804 - 240,136,305 -
ENST00001101413 COPS9-210 protein_coding not available ENSP00000771219.1 2:240,130,804 - 240,136,321 -
ENST00001145286 COPS9-211 protein_coding not available ENSP00000814532.1 2:240,130,804 - 240,136,305 -
ENST00001101410 COPS9-207 protein_coding not available ENSP00000771216.1 2:240,130,824 - 240,136,321 -
ENST00001101411 COPS9-208 protein_coding not available ENSP00000771217.1 2:240,130,824 - 240,136,321 -
ENST00001101412 COPS9-209 protein_coding not available ENSP00000771218.1 2:240,130,824 - 240,136,305 -
ENST00000489698 COPS9-203 protein_coding_CDS_not_defined not available not available 2:240,130,828 - 240,136,176 -
ENST00000491765 COPS9-204 retained_intron not available not available 2:240,130,828 - 240,134,290 -
ENST00000607357 COPS9-205 protein_coding not available ENSP00000475979.1 2:240,130,828 - 240,136,305 -
ENST00000403160 COPS9-202 protein_coding not available ENSP00000383946.4 2:240,133,983 - 240,136,807 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.