Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS8

protein_coding 2 237,085,877 - 237,103,208 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000198612

Gene type
protein_coding

Chromosome
2

Coordinates
237,085,877 - 237,103,208

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

10920 CCDS2517 CCDS42835 COP9 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) CSN8 ENST00000354371.7 MGC1297 NM_006710 NM_006710.5 Q99627 SGN8

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS8; HGNC name=COP9 signalosome subunit 8; alias_count=12; RefSeq=NM_006710; UniProt=Q99627; MANE Select=ENST00000354371.7,NM_006710.5

Source: GENCODE + HGNC complete set

10920 • protein-coding

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q99627 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 8 · Cytoplasm; Nucleus

Q99627 • reviewed

COP9 signalosome complex subunit 8 · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0010387 COP9 signalosome assembly (IEA)
GO:0007250 activation of NF-kappaB-inducing kinase activity (IMP)
GO:0008285 negative regulation of cell population proliferation (IMP)
GO:0000338 protein deneddylation (IEA)
GO:0000338 protein deneddylation (IDA)
GO:0045116 protein neddylation (NAS)
GO:0006468 protein phosphorylation (IDA)
GO:2000434 regulation of protein neddylation (NAS)

Cellular component

GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IPI)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IBA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (IDA)

+ 13 more

Molecular function

GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000354371

Representative protein
ENSP00000346340.2

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000409334	COPS8-203	protein_coding	not available	ENSP00000387212.1	2:237,085,877 - 237,103,208 +
ENST00000855904	COPS8-208	protein_coding	not available	ENSP00000525963.1	2:237,085,877 - 237,103,208 +
ENST00000855905	COPS8-209	protein_coding	not available	ENSP00000525964.1	2:237,085,877 - 237,103,208 +
ENST00000855906	COPS8-210	protein_coding	not available	ENSP00000525965.1	2:237,085,877 - 237,103,208 +
ENST00000930830	COPS8-211	protein_coding	not available	ENSP00000600889.1	2:237,085,877 - 237,103,208 +
ENST00001063598	COPS8-215	protein_coding	not available	ENSP00000733404.1	2:237,085,877 - 237,098,706 +
ENST00001129007	COPS8-218	protein_coding	not available	ENSP00000798812.1	2:237,085,877 - 237,098,700 +
ENST00001145282	COPS8-219	protein_coding	not available	ENSP00000808266.1	2:237,085,877 - 237,103,208 +
ENST00000392008	COPS8-202	protein_coding	not available	ENSP00000375865.2	2:237,085,882 - 237,103,208 +
ENST00000470452	COPS8-207	retained_intron	not available	not available	2:237,085,886 - 237,095,881 +
ENST00000354371	COPS8-201	protein_coding	not available	ENSP00000346340.2	2:237,085,889 - 237,100,474 +
ENST00000986711	COPS8-212	nonsense_mediated_decay	not available	ENSP00000656528.1	2:237,085,889 - 237,098,695 +
ENST00000986712	COPS8-213	nonsense_mediated_decay	not available	ENSP00000656529.1	2:237,085,889 - 237,098,691 +
ENST00001063601	COPS8-216	nonsense_mediated_decay	not available	ENSP00000733407.1	2:237,085,907 - 237,098,693 +
ENST00000419015	COPS8-204	nonsense_mediated_decay	not available	ENSP00000388655.1	2:237,085,909 - 237,094,186 +
ENST00001011912	COPS8-214	nonsense_mediated_decay	not available	ENSP00000681729.1	2:237,085,910 - 237,098,034 +
ENST00001093778	COPS8-217	nonsense_mediated_decay	not available	ENSP00000763584.1	2:237,085,930 - 237,098,036 +
ENST00000447464	COPS8-205	nonsense_mediated_decay	not available	ENSP00000413696.1	2:237,094,139 - 237,099,143 +
ENST00000465362	COPS8-206	retained_intron	not available	not available	2:237,096,678 - 237,098,160 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.