Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS7B

COPS7B

protein_coding 2 231,781,660 - 231,809,254 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000144524
Gene type
protein_coding
Chromosome
2
Coordinates
231,781,660 - 231,809,254
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

64708 CCDS2488 CCDS63152 CCDS63153 CCDS63154 CCDS74668 CCDS77539 COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) CSN7B ENST00000350033.8 NM_022730 NM_022730.4 Q9H9Q2

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS7B; HGNC name=COP9 signalosome subunit 7B; alias_count=16; RefSeq=NM_022730; UniProt=Q9H9Q2; MANE Select=ENST00000350033.8,NM_022730.4

Source: GENCODE + HGNC complete set

64708 • protein-coding

Alliance of Genome Resources Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q9H9Q2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7b · Cytoplasm; Nucleus

Q9H9Q2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7b · Cytoplasm; Nucleus

Q9H9Q2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7b · Cytoplasm; Nucleus

Q9H9Q2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7b · Cytoplasm; Nucleus

Q9H9Q2 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7b · Cytoplasm; Nucleus

GO annotations

Biological process
  • GO:0010387 COP9 signalosome assembly (IEA)
  • GO:0000338 protein deneddylation (IDA)
  • GO:2000434 regulation of protein neddylation (NAS)
Cellular component
  • GO:0008180 COP9 signalosome (IEA)
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0008180 COP9 signalosome (IBA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005654 nucleoplasm (IDA)
  • GO:0005654 nucleoplasm (TAS)
  • GO:0005654 nucleoplasm (TAS)

+ 3 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000350033
Representative protein
ENSP00000272995.5
Representative type
CCDS
Candidate count
16

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000409295 COPS7B-205 protein_coding not available ENSP00000386438.1 2:231,781,660 - 231,809,254 +
ENST00000994574 COPS7B-232 protein_coding not available ENSP00000664391.1 2:231,781,660 - 231,809,254 +
ENST00000410024 COPS7B-207 protein_coding not available ENSP00000386567.1 2:231,781,671 - 231,809,254 +
ENST00000611614 COPS7B-223 protein_coding not available ENSP00000484363.1 2:231,781,671 - 231,809,254 +
ENST00000994577 COPS7B-234 protein_coding not available ENSP00000664394.1 2:231,781,684 - 231,809,254 +
ENST00000409091 COPS7B-204 protein_coding not available ENSP00000386527.1 2:231,781,685 - 231,809,254 +
ENST00001022962 COPS7B-235 nonsense_mediated_decay not available ENSP00000692779.1 2:231,781,685 - 231,808,722 +
ENST00000994576 COPS7B-233 nonsense_mediated_decay not available ENSP00000664393.1 2:231,781,687 - 231,809,248 +
ENST00001022963 COPS7B-236 nonsense_mediated_decay not available ENSP00000692780.1 2:231,781,694 - 231,808,721 +
ENST00001022964 COPS7B-237 nonsense_mediated_decay not available ENSP00000692781.1 2:231,781,700 - 231,808,722 +
ENST00000449784 COPS7B-214 nonsense_mediated_decay not available ENSP00000401235.1 2:231,781,707 - 231,796,311 +
ENST00000452375 COPS7B-216 protein_coding_CDS_not_defined not available not available 2:231,781,707 - 231,791,169 +
ENST00000479430 COPS7B-220 retained_intron not available not available 2:231,781,707 - 231,788,927 +
ENST00000466901 COPS7B-218 retained_intron not available not available 2:231,781,708 - 231,791,976 +
ENST00000956209 COPS7B-231 protein_coding not available ENSP00000626268.1 2:231,781,731 - 231,809,254 +
ENST00000876254 COPS7B-226 protein_coding not available ENSP00000546313.1 2:231,786,281 - 231,809,254 +
ENST00001084803 COPS7B-242 nonsense_mediated_decay not available ENSP00000754609.1 2:231,786,346 - 231,809,245 +
ENST00000620578 COPS7B-224 protein_coding not available ENSP00000484579.1 2:231,786,383 - 231,809,254 +
ENST00001022966 COPS7B-238 nonsense_mediated_decay not available ENSP00000692783.1 2:231,786,425 - 231,808,722 +
ENST00001084804 COPS7B-243 nonsense_mediated_decay not available ENSP00000754610.1 2:231,786,431 - 231,809,248 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.