Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS7A

COPS7A

protein_coding 12 6,724,014 - 6,732,462 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000111652
Gene type
protein_coding
Chromosome
12
Coordinates
6,724,014 - 6,732,462
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

50813 CCDS8558 COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) CSN7A ENST00000543155.6 NM_001164093 NM_001164094.2 Q9UBW8

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS7A; HGNC name=COP9 signalosome subunit 7A; alias_count=11; RefSeq=NM_001164093; UniProt=Q9UBW8; MANE Select=ENST00000543155.6,NM_001164094.2

Source: GENCODE + HGNC complete set

50813 • protein-coding

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

NCBI Gene

UniProt

Q9UBW8 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7a · Cytoplasm; Nucleus

Q9UBW8 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7a · Cytoplasm; Nucleus

Q9UBW8 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7a · Cytoplasm; Nucleus

Q9UBW8 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7a · Cytoplasm; Nucleus

Q9UBW8 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 7a · Cytoplasm; Nucleus

GO annotations

Biological process
  • GO:0010387 COP9 signalosome assembly (IEA)
  • GO:0000338 protein deneddylation (IDA)
  • GO:0045116 protein neddylation (NAS)
  • GO:2000434 regulation of protein neddylation (NAS)
Cellular component
  • GO:0008180 COP9 signalosome (IEA)
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0008180 COP9 signalosome (IPI)
  • GO:0008180 COP9 signalosome (IBA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005829 cytosol (IDA)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 7 more

Molecular function
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

Representative

Representative transcript
ENST00000229251
Representative protein
ENSP00000229251.3
Representative type
CCDS
Candidate count
18

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000229251 COPS7A-201 protein_coding not available ENSP00000229251.3 12:6,724,014 - 6,731,875 +
ENST00000889557 COPS7A-222 protein_coding not available ENSP00000559616.1 12:6,724,014 - 6,731,875 +
ENST00000889559 COPS7A-224 protein_coding not available ENSP00000559618.1 12:6,724,014 - 6,731,875 +
ENST00000889563 COPS7A-228 protein_coding not available ENSP00000559622.1 12:6,724,014 - 6,731,875 +
ENST00000956855 COPS7A-247 protein_coding not available ENSP00000626914.1 12:6,724,014 - 6,731,875 +
ENST00001039238 COPS7A-259 nonsense_mediated_decay not available ENSP00000709055.1 12:6,724,014 - 6,732,462 +
ENST00000538410 COPS7A-208 protein_coding not available ENSP00000439547.1 12:6,724,022 - 6,731,875 +
ENST00000889558 COPS7A-223 protein_coding not available ENSP00000559617.1 12:6,724,022 - 6,731,875 +
ENST00000889560 COPS7A-225 protein_coding not available ENSP00000559619.1 12:6,724,022 - 6,731,875 +
ENST00000889562 COPS7A-227 protein_coding not available ENSP00000559621.1 12:6,724,022 - 6,731,875 +
ENST00000889572 COPS7A-237 protein_coding not available ENSP00000559631.1 12:6,724,022 - 6,731,875 +
ENST00000928876 COPS7A-239 protein_coding not available ENSP00000598935.1 12:6,724,022 - 6,731,875 +
ENST00000956856 COPS7A-248 protein_coding not available ENSP00000626915.1 12:6,724,022 - 6,731,875 +
ENST00000956857 COPS7A-249 protein_coding not available ENSP00000626916.1 12:6,724,022 - 6,731,875 +
ENST00000999377 COPS7A-253 nonsense_mediated_decay not available ENSP00000669194.1 12:6,724,022 - 6,731,868 +
ENST00000999378 COPS7A-254 nonsense_mediated_decay not available ENSP00000669195.1 12:6,724,022 - 6,731,868 +
ENST00001039243 COPS7A-262 nonsense_mediated_decay not available ENSP00000709060.1 12:6,724,022 - 6,731,856 +
ENST00001117866 COPS7A-276 protein_coding not available ENSP00000787671.1 12:6,724,022 - 6,731,873 +
ENST00001123136 COPS7A-278 protein_coding not available ENSP00000792941.1 12:6,724,022 - 6,731,867 +
ENST00001123137 COPS7A-279 protein_coding not available ENSP00000792942.1 12:6,724,022 - 6,731,868 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.