Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS6

protein_coding 7 100,088,948 - 100,095,185 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000168090

Gene type
protein_coding

Chromosome
7

Coordinates
100,088,948 - 100,095,185

Strand
+

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

10980 CCDS5682 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) COP9 subunit 6 (MOV34 homolog, 34 kD) CSN6 ENST00000303904.8 MOV34-34KD NM_006833 NM_006833.5 Q7L5N1

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS6; HGNC name=COP9 signalosome subunit 6; alias_count=11; RefSeq=NM_006833; UniProt=Q7L5N1; MANE Select=ENST00000303904.8,NM_006833.5

Source: GENCODE + HGNC complete set

10980 • protein-coding

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

NCBI Gene

UniProt

Q7L5N1 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets

COP9 signalosome complex subunit 6 · Nucleus; Cytoplasm; Cytoplasm, perinuclear region

GO annotations

Biological process

GO:0000338 protein deneddylation (IEA)
GO:0000338 protein deneddylation (IDA)
GO:0045116 protein neddylation (NAS)
GO:2000434 regulation of protein neddylation (NAS)

Cellular component

GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IEA)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IPI)
GO:0008180 COP9 signalosome (IBA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005737 cytoplasm (EXP)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)

+ 9 more

Molecular function

GO:0140492 metal-dependent deubiquitinase activity (IKR)
GO:0008233 peptidase activity (IKR)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 36 more

Representative

Representative transcript
ENST00000303904

Representative protein
ENSP00000304102.3

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000418625	COPS6-202	protein_coding	not available	ENSP00000400617.1	7:100,088,948 - 100,092,200 +
ENST00000908037	COPS6-211	protein_coding	not available	ENSP00000578096.1	7:100,088,948 - 100,093,340 +
ENST00000908038	COPS6-212	protein_coding	not available	ENSP00000578097.1	7:100,088,948 - 100,093,338 +
ENST00000908039	COPS6-213	protein_coding	not available	ENSP00000578098.1	7:100,088,948 - 100,092,200 +
ENST00000908040	COPS6-214	protein_coding	not available	ENSP00000578099.1	7:100,088,948 - 100,092,200 +
ENST00000908041	COPS6-215	protein_coding	not available	ENSP00000578100.1	7:100,088,948 - 100,092,200 +
ENST00000908042	COPS6-216	protein_coding	not available	ENSP00000578101.1	7:100,088,948 - 100,092,200 +
ENST00000908043	COPS6-217	protein_coding	not available	ENSP00000578102.1	7:100,088,948 - 100,092,200 +
ENST00000908044	COPS6-218	protein_coding	not available	ENSP00000578103.1	7:100,088,948 - 100,092,200 +
ENST00000908045	COPS6-219	protein_coding	not available	ENSP00000578104.1	7:100,088,948 - 100,092,200 +
ENST00000920061	COPS6-220	protein_coding	not available	ENSP00000590120.1	7:100,088,948 - 100,092,200 +
ENST00000920062	COPS6-221	protein_coding	not available	ENSP00000590121.1	7:100,088,948 - 100,092,200 +
ENST00000920063	COPS6-222	protein_coding	not available	ENSP00000590122.1	7:100,088,948 - 100,092,200 +
ENST00000920064	COPS6-223	protein_coding	not available	ENSP00000590123.1	7:100,088,948 - 100,092,200 +
ENST00000920065	COPS6-224	protein_coding	not available	ENSP00000590124.1	7:100,088,948 - 100,092,200 +
ENST00000920066	COPS6-225	protein_coding	not available	ENSP00000590125.1	7:100,088,948 - 100,092,200 +
ENST00000920067	COPS6-226	protein_coding	not available	ENSP00000590126.1	7:100,088,948 - 100,092,200 +
ENST00000920068	COPS6-227	protein_coding	not available	ENSP00000590127.1	7:100,088,948 - 100,092,200 +
ENST00000955918	COPS6-228	protein_coding	not available	ENSP00000625977.1	7:100,088,948 - 100,092,200 +
ENST00001011473	COPS6-231	protein_coding	not available	ENSP00000681290.1	7:100,088,948 - 100,092,200 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.