Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS4

COPS4

protein_coding 4 83,034,447 - 83,075,818 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000138663
Gene type
protein_coding
Chromosome
4
Coordinates
83,034,447 - 83,075,818
Strand
+
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

51138 CCDS3600 CCDS58909 CCDS82935 COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) CSN4 ENST00000264389.7 NM_001258006 NM_016129.3 Q9BT78 SGN4

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS4; HGNC name=COP9 signalosome subunit 4; alias_count=14; RefSeq=NM_001258006; UniProt=Q9BT78; MANE Select=ENST00000264389.7,NM_016129.3

Source: GENCODE + HGNC complete set

51138 • protein-coding

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

NCBI Gene

UniProt

Q9BT78 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 4 · Cytoplasm; Nucleus; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle

Q9BT78 • reviewed

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

COP9 signalosome complex subunit 4 · Cytoplasm; Nucleus; Cytoplasmic vesicle, secretory vesicle, synaptic vesicle

GO annotations

Biological process
  • GO:0000338 protein deneddylation (IDA)
  • GO:0000338 protein deneddylation (IMP)
  • GO:0045116 protein neddylation (NAS)
  • GO:2000434 regulation of protein neddylation (NAS)
Cellular component
  • GO:0008180 COP9 signalosome (IEA)
  • GO:0008180 COP9 signalosome (IDA)
  • GO:0008180 COP9 signalosome (IPI)
  • GO:0008180 COP9 signalosome (IBA)
  • GO:0005737 cytoplasm (IEA)
  • GO:0005737 cytoplasm (IDA)
  • GO:0005737 cytoplasm (EXP)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)
  • GO:0005829 cytosol (TAS)

+ 13 more

Molecular function
  • GO:0019784 deNEDDylase activity (TAS)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)

+ 14 more

Representative

Representative transcript
ENST00000264389
Representative protein
ENSP00000264389.2
Representative type
CCDS
Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000503682 COPS4-202 protein_coding not available ENSP00000424791.1 4:83,034,447 - 83,075,818 +
ENST00000509093 COPS4-206 protein_coding not available ENSP00000425976.1 4:83,034,447 - 83,075,818 +
ENST00000873600 COPS4-212 protein_coding not available ENSP00000543659.1 4:83,034,447 - 83,075,818 +
ENST00000873601 COPS4-213 protein_coding not available ENSP00000543660.1 4:83,034,447 - 83,075,818 +
ENST00000873602 COPS4-214 protein_coding not available ENSP00000543661.1 4:83,034,447 - 83,075,818 +
ENST00000873603 COPS4-215 protein_coding not available ENSP00000543662.1 4:83,034,447 - 83,075,818 +
ENST00000928044 COPS4-216 protein_coding not available ENSP00000598103.1 4:83,034,447 - 83,075,818 +
ENST00000942933 COPS4-217 protein_coding not available ENSP00000612992.1 4:83,034,447 - 83,075,818 +
ENST00000942934 COPS4-218 protein_coding not available ENSP00000612993.1 4:83,034,447 - 83,075,818 +
ENST00000988002 COPS4-220 protein_coding not available ENSP00000657819.1 4:83,034,447 - 83,075,816 +
ENST00000988004 COPS4-222 protein_coding not available ENSP00000657821.1 4:83,034,447 - 83,051,116 +
ENST00001038793 COPS4-227 protein_coding not available ENSP00000708610.1 4:83,034,447 - 83,075,818 +
ENST00001107446 COPS4-231 protein_coding not available ENSP00000777251.1 4:83,034,447 - 83,068,969 +
ENST00001107447 COPS4-232 protein_coding not available ENSP00000777252.1 4:83,034,447 - 83,048,012 +
ENST00001133961 COPS4-233 protein_coding not available ENSP00000803607.1 4:83,034,447 - 83,075,818 +
ENST00001038788 COPS4-223 nonsense_mediated_decay not available ENSP00000708605.1 4:83,035,069 - 83,075,815 +
ENST00000988001 COPS4-219 nonsense_mediated_decay not available ENSP00000657818.1 4:83,035,071 - 83,075,816 +
ENST00001038789 COPS4-224 nonsense_mediated_decay not available ENSP00000708606.1 4:83,035,082 - 83,075,811 +
ENST00001038791 COPS4-225 nonsense_mediated_decay not available ENSP00000708608.1 4:83,035,091 - 83,075,813 +
ENST00000511891 COPS4-211 retained_intron not available not available 4:83,035,171 - 83,049,515 +

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.