Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

COPS2

protein_coding 15 49,106,068 - 49,155,661 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000166200

Gene type
protein_coding

Chromosome
15

Coordinates
49,106,068 - 49,155,661

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

9318 ALIEN CCDS32235 CCDS45257 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) CSN2 ENST00000388901.10 NM_004236 NM_004236.4 P61201 TRIP15

Summary

GENCODE gene_type=protein_coding; HGNC symbol=COPS2; HGNC name=COP9 signalosome subunit 2; alias_count=11; RefSeq=NM_004236; UniProt=P61201; MANE Select=ENST00000388901.10,NM_004236.4

Source: GENCODE + HGNC complete set

9318 • protein-coding

Alliance of Genome Resources Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm and nucleus. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

P61201 • reviewed

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1

COP9 signalosome complex subunit 2 · Cytoplasm; Nucleus

P61201 • reviewed

COP9 signalosome complex subunit 2 · Cytoplasm; Nucleus

GO annotations

Biological process

GO:0000122 negative regulation of transcription by RNA polymerase II (ISS)
GO:0000122 negative regulation of transcription by RNA polymerase II (IEA)
GO:0030182 neuron differentiation (IEA)
GO:0000338 protein deneddylation (IDA)
GO:0000338 protein deneddylation (IBA)
GO:0045116 protein neddylation (NAS)
GO:0006468 protein phosphorylation (IDA)
GO:2000434 regulation of protein neddylation (NAS)
GO:0007165 signal transduction (NAS)
GO:0006366 transcription by RNA polymerase II (TAS)

Cellular component

GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IPI)
GO:0008180 COP9 signalosome (IDA)
GO:0008180 COP9 signalosome (IBA)
GO:0005737 cytoplasm (IEA)
GO:0005737 cytoplasm (IDA)
GO:0005737 cytoplasm (IDA)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)
GO:0005829 cytosol (TAS)

+ 8 more

Molecular function

GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 12 more

Representative

Representative transcript
ENST00000299259

Representative protein
ENSP00000299259.6

Representative type
CCDS

Candidate count
4

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000560240	COPS2-207	nonsense_mediated_decay	not available	ENSP00000453546.1	15:49,106,068 - 49,130,773 -
ENST00000299259	COPS2-201	protein_coding	not available	ENSP00000299259.6	15:49,122,727 - 49,155,661 -
ENST00000388901	COPS2-202	protein_coding	not available	ENSP00000373553.5	15:49,122,727 - 49,155,599 -
ENST00000542928	COPS2-203	protein_coding	not available	ENSP00000443664.1	15:49,122,727 - 49,155,661 -
ENST00000882488	COPS2-209	protein_coding	not available	ENSP00000552547.1	15:49,122,727 - 49,155,661 -
ENST00000882489	COPS2-210	protein_coding	not available	ENSP00000552548.1	15:49,122,727 - 49,155,661 -
ENST00000882490	COPS2-211	protein_coding	not available	ENSP00000552549.1	15:49,122,727 - 49,155,661 -
ENST00000882491	COPS2-212	protein_coding	not available	ENSP00000552550.1	15:49,122,727 - 49,155,661 -
ENST00000882492	COPS2-213	protein_coding	not available	ENSP00000552551.1	15:49,122,727 - 49,155,661 -
ENST00000940241	COPS2-214	protein_coding	not available	ENSP00000610300.1	15:49,122,727 - 49,155,661 -
ENST00001133540	COPS2-221	protein_coding	not available	ENSP00000811395.1	15:49,122,727 - 49,155,661 -
ENST00001066728	COPS2-220	nonsense_mediated_decay	not available	ENSP00000736534.1	15:49,125,283 - 49,155,605 -
ENST00001024420	COPS2-217	nonsense_mediated_decay	not available	ENSP00000694237.1	15:49,125,468 - 49,155,614 -
ENST00001024422	COPS2-218	nonsense_mediated_decay	not available	ENSP00000694239.1	15:49,126,040 - 49,155,619 -
ENST00000975301	COPS2-215	protein_coding	not available	ENSP00000645118.1	15:49,127,345 - 49,155,661 -
ENST00001024425	COPS2-219	nonsense_mediated_decay	not available	ENSP00000694242.1	15:49,127,346 - 49,155,614 -
ENST00000975302	COPS2-216	nonsense_mediated_decay	not available	ENSP00000645119.1	15:49,127,353 - 49,155,616 -
ENST00000558843	COPS2-205	protein_coding	not available	ENSP00000452944.1	15:49,134,033 - 49,155,590 -
ENST00000561248	COPS2-208	protein_coding	not available	ENSP00000453412.1	15:49,134,083 - 49,155,604 -
ENST00000559016	COPS2-206	retained_intron	not available	not available	15:49,134,135 - 49,137,459 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

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ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.