Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

BRD7

protein_coding 16 50,313,487 - 50,369,059 PDO SQLite primary read-only query mode

Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000166164

Gene type
protein_coding

Chromosome
16

Coordinates
50,313,487 - 50,369,059

Strand
-

Status
not available

NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

29117 BP75 CCDS10742 CCDS54007 CELTIX1 ENST00000394688.8 NM_013263 NM_013263.5 Q9NPI1 SMARCI1 bromodomain-containing 7

Summary

GENCODE gene_type=protein_coding; HGNC symbol=BRD7; HGNC name=bromodomain containing 7; alias_count=11; RefSeq=NM_013263; UniProt=Q9NPI1; MANE Select=ENST00000394688.8,NM_013263.5

Source: GENCODE + HGNC complete set

29117 • protein-coding

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

NCBI Gene

UniProt

Q9NPI1 • reviewed

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase

Bromodomain-containing protein 7 · Nucleus; Chromosome

Q9NPI1 • reviewed

Bromodomain-containing protein 7 · Nucleus; Chromosome

GO annotations

Biological process

GO:0006338 chromatin remodeling (NAS)
GO:0045892 negative regulation of DNA-templated transcription (IDA)
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle (IDA)
GO:0045893 positive regulation of DNA-templated transcription (IEA)
GO:0045582 positive regulation of T cell differentiation (NAS)
GO:0045597 positive regulation of cell differentiation (NAS)
GO:2000781 positive regulation of double-strand break repair (NAS)
GO:0045663 positive regulation of myoblast differentiation (NAS)
GO:0070316 regulation of G0 to G1 transition (NAS)
GO:2000045 regulation of G1/S transition of mitotic cell cycle (NAS)

+ 7 more

Cellular component

GO:0016586 RSC-type complex (NAS)
GO:0000785 chromatin (NAS)
GO:0005694 chromosome (IEA)
GO:0005694 chromosome (EXP)
GO:0005737 cytoplasm (TAS)
GO:0000776 kinetochore (NAS)
GO:0016363 nuclear matrix (NAS)
GO:0005654 nucleoplasm (IDA)
GO:0005654 nucleoplasm (TAS)
GO:0005654 nucleoplasm (TAS)

+ 15 more

Molecular function

GO:0140015 histone H3K14ac reader activity (IDA)
GO:0042393 histone binding (IDA)
GO:0140566 histone reader activity (IBA)
GO:0002039 p53 binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)
GO:0005515 protein binding (IPI)

+ 7 more

Representative

Representative transcript
ENST00000394688

Representative protein
ENSP00000378180.3

Representative type
CCDS

Candidate count
5

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID	Name	Type	Status	Protein	Location
ENST00000562383	BRD7-205	protein_coding	not available	ENSP00000458430.1	16:50,313,487 - 50,319,929 -
ENST00000394689	BRD7-202	protein_coding	not available	ENSP00000378181.2	16:50,313,488 - 50,369,059 -
ENST00000710356	BRD7-208	protein_coding	not available	ENSP00000518227.1	16:50,313,488 - 50,369,059 -
ENST00000710357	BRD7-209	protein_coding	not available	ENSP00000518228.1	16:50,313,488 - 50,369,059 -
ENST00001135345	BRD7-210	protein_coding	not available	ENSP00000811743.1	16:50,313,488 - 50,369,059 -
ENST00000569774	BRD7-207	protein_coding	not available	ENSP00000461556.1	16:50,315,947 - 50,320,377 -
ENST00000394688	BRD7-201	protein_coding	not available	ENSP00000378180.3	16:50,315,957 - 50,368,988 -
ENST00000475877	BRD7-204	protein_coding_CDS_not_defined	not available	not available	16:50,334,711 - 50,361,833 -
ENST00000401491	BRD7-203	protein_coding_CDS_not_defined	not available	not available	16:50,349,023 - 50,368,920 -
ENST00000567826	BRD7-206	retained_intron	not available	not available	16:50,350,017 - 50,368,920 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.