Human_Genes_Functions
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Prototype stage

Gene detail

Read-only gene view with summary, GO, UniProt, NCBI, and representative sequence links.

GRCh38.p14 + GENCODE Release 50local-onlyPDO SQLite primaryread-only query modesqlite3 fallback available

Gene detail

ASTE1

ASTE1

protein_coding 3 131,013,065 - 131,027,649 PDO SQLite primary read-only query mode
Overview Summary GO UniProt Representative Transcripts FASTA ClinVar disease associations

Overview

Gene ID
ENSG00000034533
Gene type
protein_coding
Chromosome
3
Coordinates
131,013,065 - 131,027,649
Strand
-
Status
not available
NCBI summary UniProt GO Transcript FASTA Protein FASTA

Aliases

28990 CCDS3068 CCDS75007 ENST00000264992.8 HT001 NM_014065 NM_014065.4 Q2TB18 asteroid homolog 1 asteroid homolog 1 (Drosophila)

Summary

GENCODE gene_type=protein_coding; HGNC symbol=ASTE1; HGNC name=asteroid structure-specific endonuclease 1; alias_count=10; RefSeq=NM_014065; UniProt=Q2TB18; MANE Select=ENST00000264992.8,NM_014065.4

Source: GENCODE + HGNC complete set

28990 • protein-coding

Alliance of Genome Resources Enables 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via homologous recombination and double-strand break repair via nonhomologous end joining. Implicated in Lynch syndrome and mismatch repair cancer syndrome. [provided by Alliance of Genome Resources, Jul 2025]

NCBI Gene

UniProt

Q2TB18 • reviewed

Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ)

Single-strand DNA endonuclease ASTE1

Q2TB18 • reviewed

Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ)

Single-strand DNA endonuclease ASTE1

GO annotations

Biological process
  • GO:0006310 DNA recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (IEA)
  • GO:0000724 double-strand break repair via homologous recombination (IMP)
  • GO:0006303 double-strand break repair via nonhomologous end joining (IEA)
  • GO:0006303 double-strand break repair via nonhomologous end joining (IMP)
Molecular function
  • GO:1990599 3' overhang single-stranded DNA endonuclease activity (IDA)
  • GO:0004520 DNA endonuclease activity (IEA)
  • GO:0004518 nuclease activity (IEA)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0005515 protein binding (IPI)
  • GO:0000014 single-stranded DNA endonuclease activity (IDA)

Representative

Representative transcript
ENST00000264992
Representative protein
ENSP00000264992.3
Representative type
CCDS
Candidate count
13

GENCODE Release 50 annotation GTF · transcript.tag=CCDS; transcript_support_level=1

Transcript FASTA Protein FASTA

Transcripts

Transcript ID Name Type Status Protein Location
ENST00000997186 ASTE1-219 nonsense_mediated_decay not available ENSP00000667003.1 3:131,013,065 - 131,026,825 -
ENST00000514044 ASTE1-208 protein_coding not available ENSP00000426421.1 3:131,013,066 - 131,026,825 -
ENST00000874886 ASTE1-209 protein_coding not available ENSP00000544945.1 3:131,013,066 - 131,026,825 -
ENST00000874887 ASTE1-210 protein_coding not available ENSP00000544946.1 3:131,013,066 - 131,026,859 -
ENST00000874888 ASTE1-211 protein_coding not available ENSP00000544947.1 3:131,013,066 - 131,026,849 -
ENST00000874889 ASTE1-212 protein_coding not available ENSP00000544948.1 3:131,013,066 - 131,026,825 -
ENST00000928636 ASTE1-213 protein_coding not available ENSP00000598695.1 3:131,013,066 - 131,026,859 -
ENST00000928637 ASTE1-214 protein_coding not available ENSP00000598696.1 3:131,013,066 - 131,026,859 -
ENST00000928638 ASTE1-215 protein_coding not available ENSP00000598697.1 3:131,013,066 - 131,026,825 -
ENST00000928639 ASTE1-216 protein_coding not available ENSP00000598698.1 3:131,013,066 - 131,026,859 -
ENST00000972329 ASTE1-217 protein_coding not available ENSP00000642388.1 3:131,013,066 - 131,027,018 -
ENST00000972330 ASTE1-218 protein_coding not available ENSP00000642389.1 3:131,013,066 - 131,026,791 -
ENST00001140143 ASTE1-228 protein_coding not available ENSP00000803688.1 3:131,013,066 - 131,026,825 -
ENST00001010607 ASTE1-224 nonsense_mediated_decay not available ENSP00000680424.1 3:131,013,870 - 131,026,773 -
ENST00000264992 ASTE1-201 protein_coding not available ENSP00000264992.3 3:131,013,875 - 131,026,825 -
ENST00001075718 ASTE1-226 protein_coding not available ENSP00000745524.1 3:131,013,875 - 131,026,859 -
ENST00001075719 ASTE1-227 nonsense_mediated_decay not available ENSP00000745525.1 3:131,013,877 - 131,026,757 -
ENST00001010605 ASTE1-222 nonsense_mediated_decay not available ENSP00000680422.1 3:131,013,879 - 131,026,825 -
ENST00000997187 ASTE1-220 nonsense_mediated_decay not available ENSP00000667004.1 3:131,013,880 - 131,026,793 -
ENST00001010606 ASTE1-223 protein_coding not available ENSP00000680423.1 3:131,013,880 - 131,026,825 -

FASTA

FASTA output is generated by backend query; the raw FASTA path is not exposed.

Open transcript export Open protein export

ClinVar disease associations

ClinVar disease associations: 0

ClinVar gene-disease tables are missing. Build the candidate database first.